Many epidemiologic studies have studied the relationship between coffee consumption and the risk of heart disease. These aspects in combination could lead to diseases or health problems. However, the majority of epidemiological studies regarding this relationship have not yielded a clear conclusion, mainly due to the lack of concrete and continuous information regarding the frequency of consumption, the exact composition of the beverage, and factors associated with an unhealthy lifestyle (cigarette smoking, alcohol, and sedentarism). Of the alkaloids, the most studied and recognized one is caffeine, which makes up 1.3 to 2.4% of the bean's weight followed by other purinic alkaloids such as theobromine and theophylline and pyridine such as trigonelline.Ĭoffee consumption is generally associated with a large number of diseases and health alterations. They also contain minerals, aliphatic and chlorogenic acids, trigonellines, and volatile aromas. Melanoidins make up 23% of the weight and are what give the beans their brown color. The major component of coffee is carbohydrates, which make up 38–42% of the toasted coffee bean, followed by lipids and amino acids with about 20 and 10%, respectively. Over 2,000 substances have been isolated from coffee. There are approximately 590 coffee growing municipalities, 513,000 coffee growers, 640,000 direct employees, and more than a million indirect employees, which means approximately 2 million people dependent on coffee cultivation It has been produced in Colombia since the nineteenth century and is the main export to more than 36 countries in 2008 it represented close to 12.4% of the harvest of mild Arabica type coffee and 12.2% of worldwide coffee exports. Coffee is one of the most frequently consumed beverages in the world.
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